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KMID : 0613820130230010063
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Journal of Life Science
2013 Volume.23 No. 1 p.63 ~ p.68
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Effect of Black Garlic Extract on Cytokine Generation of Mouse Spleen Cells
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Seo Min-Jeong
Kang Byoung-Won
Park Jeong-Uck
Kim Min-Jeong
Lee Hye-Hyeon
Ryu En-Ju
Joo Woo-Hong
Kim Kwang-Hyuk
Jeong Yong-Kee
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Abstract
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The effect of black garlic extract on the activation of spleen cells from a C57BL6 mouse was investigated to examine immune activities of of fermented black garlic containing a variety of bioactive substances. xtract obtained from the concentration of commercial Namhae black garlic was used for the analysis of immune activities. Treatment with the extract increased the expression of interleukin-2 (IL-2) cytokine. The simultaneous administration of the extract plus lipopolysaccharide (LPS) increased the expression of IL-2, tumor necrosis factor (TNF)-α, and interferon (IFN)-r compared with that of a control group. This result suggests that cellular immunity can be induced by macrophages, resulting in the expression of T lymphocytes and T helper type 1 (Th1) cells. In addition, treatment with the extract increased the late response of IL-6 cytokines, and the extract plus LPS augmented the expression of IL-4 and IL-6 compared with that of an LPS-treated group. Meanwhile, the extract plus LPS decreased the late response of IL-10, suggesting that humoral immunity can be activated by stimulating B lymphocytes, suppressing cellular immunity, and effectively modulating the conversion into humoral immune responses. These findings demonstrate that the black garlic extract activates Th1 and Th2 cells by stimulating T lymphocytes in mouse spleen cells and leads to immunomodulation by activating cellular and humoral immune responses of the immune system.
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KEYWORD
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Black garlic extract, cytokine, T lymphocytes
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